Virulence Factors Of Uropathogenic Proteus Mirabilis - A Mini Review

Effect of Ibicella lutea on uropathogenic Proteus mirabilis growth, virulence, and biofilm formation.

BACKGROUND Proteus mirabilis, an important uropathogen that can cause complicated urinary tract infections (UTI), has emerged as a therapeutic problem following mutations that compromise the use of antimicrobial drugs. Due to the serious effects associated with uropathogenic P. mirabilis and the problems related to the use of antibiotics, it is necessary to develop alternative strategies for it...

The RNA Chaperone Hfq Is Involved in Stress Tolerance and Virulence in Uropathogenic Proteus mirabilis

Hfq is a bacterial RNA chaperone involved in the riboregulation of diverse genes via small noncoding RNAs. Here, we show that Hfq is critical for the uropathogenic Proteus mirabilis to effectively colonize the bladder and kidneys in a murine urinary tract infection (UTI) model and to establish burned wound infection of the rats. In this regard, we found the hfq mutant induced higher IL-8 and MI...

Plasmids and Putative Virulence Characters in Proteus mirabilis

A novel autotransporter of uropathogenic Proteus mirabilis is both a cytotoxin and an agglutinin.

One of the six predicted Proteus mirabilis autotransporters (ATs), ORF c2341, is predicted to contain a serine protease motif and was earlier identified as an immunogenic outer membrane protein in P. mirabilis. The 3.2 kb gene encodes a 117 kDa protein with a 58-amino-acid-long signal peptide, a 75-kDa-long N-terminal passenger domain and a 30-kDa-long C-terminal translocator. Affinity-purified...

Quantification of Proteus mirabilis virulence factors and modulation by acylated homoserine lactones.

BACKGROUND AND PURPOSE Measurement of the main Proteus mirabilis virulence factors would increase our understanding of how the organism infects and colonizes the urinary tract. The purpose of this study was to quantify the virulence factors of twelve P. mirabilis laboratory strains and to determine whether expression of virulence factors of P. mirabilis depends on the presence of homoserine-lac...